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| Jeff Goldblum | Seth Brundle |
| Geena Davis | Veronica Quaife |
| John Getz | Stathis Borans |
| Joy Boushel | Tawny |
| Les Carlson | Dr. Brent Cheevers |
| George Chuvalo | Marky |
| Michael Copeman | 2nd Man in Bar |
| David Cronenberg | Gynecologist |
| Carol Lazare | Nurse |
| Shawn Hewitt | Clerk |
When scientist Seth Brundle completes his teleportation device, he decides to test its abilities on himself. Unbeknownst to him, a housefly slips in during the process, leading to a merger of man and insect. Initially, Brundle appears to have undergone a successful teleportation, but the fly's cells begin to take over his body. As he becomes increasingly fly-like, Brundle's girlfriend is horrified as the person she once loved deteriorates into a monster.
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