|Mathieu Amalric||Jean-Dominique Bauby|
|Emmanuelle Seigner||Celine Desmoulin|
|Marie-Josée Croze||Henriette Durand|
|Patrick Chesnais||Dr. Lepage|
|Olatz Lopez Garmendia||Marie Lopez|
|Jean-Pierre Cassel||Father Lucien|
|Max Von Sydow||Papinou|
Jean-Dominique Bauby, editor-in-chief of French fashion bible Elle magazine, has a devastating stroke at age 43. The damage to his brain stem results in locked-in syndrome, with which he is almost completely paralyzed and only able to communicate by blinking an eye. Bauby painstakingly dictates his memoir via the only means of expression left to him.