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| Johnny Depp | Commander Spencer Armacost |
| Charlize Theron | Jillian Armacost |
| Joe Morton | Sherman Reese, NASA Representative |
| Clea DuVall | Nan |
| Donna Murphy | Natalie Streck |
| Nick Cassavetes | Capt. Alex Streck |
| Samantha Eggar | Dr. Patraba |
| Gary Grubbs | NASA Director |
| Blair Brown | Shelly McLaren |
| Tom Noonan | Jackson McLaren |
| Conrad Bachmann | Reporter |
| Dylan Sprouse | Twins |
| Tom O'Brien | Allen Dodge |
| Lucy Lin | Shelly Carter |
| Michael Crider | Pat Elliott |
| Jacob Stein | Calvin, 2nd Grade Student |
| Cole Sprouse | Twins |
After her husband loses consciousness during a space mission, a woman realizes he has somehow been changed.
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