|Zach Tyler Eisen||Lucas Nickle|
|Meryl Streep||Queen Ant|
|Paul Giamatti||Stan Beals|
|Ricardo Montalbán||Head of Ant Council|
|Allison Mack||Tiffany Nickle|
|Jake T. Austin||Nicky|
Tired of weathering constant attacks on their colony, ants shrink a destructive boy, named Lucas, to their size and sentence him to live among them until he learns the errors of his ways. Guided by his insect guardians, Lucas discovers a world he never knew existed and soon joins forces with his new friends to combat an exterminator who threatens their colony.