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| Mercedes Ruehl | Grace |
| Paul Sorvino | Joe |
| Cloris Leachman | Dolly |
| Sean Young | Christine |
| Dinah Manoff | Denise |
| Lily Knight | Dolores |
| Mark Harmon | Lawrence |
| Jamey Sheridan | Paul |
| Marissa Leigh | Laura |
| Doug Spinuzza | Armand |
| Sam McMurray | Brian |
| Edith Fields | Aunt Loretta |
| Joe Greco | Uncle Frankie |
| Cassie Cole | Carla |
| Matt Winston | Johnny Barlotta |
| Gary Hershberger | Kevin |
| Anne De Salvo | Cathy |
| Sal Viscuso | Father Dedice |
| Anna Berger | Stella |
| Don Marino | Sam |
| Kivi Rogers | Mike |
| John Capodice | Danny |
| Robert Picardo | Grace's Doctor |
| Fred Tucker | Stage Manager |
| Carol Ann Susi | Ticket Seller |
| Niki Harris | Flight Attendant |
| Maria Cina | Rockie's Girl |
| Larissa Joy | Italian Class Student |
| Jay Acovone | Mr. Moltianni |
A warm, emotional story centered around four sisters and the relationship they share with their recently widowed mother. While trying to help her cope, each of the sisters begins to understand what is missing in their own lives and relationships, and the lessons they learn affect the entire family. Through good times and bad, the sisters come to rely upon each other as never before. And when tragedy strikes, the family members turn to each other for comfort and support.
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