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| Mercedes Ruehl | Grace |
| Paul Sorvino | Joe |
| Cloris Leachman | Dolly |
| Sean Young | Christine |
| Dinah Manoff | Denise |
| Lily Knight | Dolores |
| Mark Harmon | Lawrence |
| Jamey Sheridan | Paul |
| Marissa Leigh | Laura |
| Doug Spinuzza | Armand |
| Sam McMurray | Brian |
| Edith Fields | Aunt Loretta |
| Joe Greco | Uncle Frankie |
| Cassie Cole | Carla |
| Matt Winston | Johnny Barlotta |
| Gary Hershberger | Kevin |
| Anne DeSalvo | Cathy |
| Sal Viscuso | Father Dedice |
| Anna Berger | Stella |
| Don Marino | Sam |
| Kivi Rogers | Mike |
| John Capodice | Danny |
| Robert Picardo | Grace's Doctor |
| Fred Tucker | Stage Manager |
| Carol Ann Susi | Ticket Seller |
| Niki Harris | Flight Attendant |
| Maria Cina | Rockie's Girl |
| Larissa Joy | Italian Class Student |
| Jay Acovone | Mr. Moltianni |
Four adult sisters help their mother cope with the recent loss of her husband.
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