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| Basil Rathbone | Sherlock Holmes |
| Nigel Bruce | Dr. Watson |
| Ida Lupino | Ann Brandon |
| Alan Marshal | Jerrold Hunter |
| Terry Kilburn | Billy |
| George Zucco | Prof. Moriarty |
| E.E. Clive | Inspector Bristol |
| Mary Gordon | Mrs. Hudson |
Sherlock Holmes and Dr. Watson square off against their archenemy, Professor Moriarty, who has designs on the Tower of London's Crown Jewels. As a perfect distraction from Moriarty's schemes, Holmes and Watson are contacted by a woman who claims that her family is in danger after her brother receives the same warning message her father got 10 years ago -- just before he was brutally murdered.
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