|Terence Stamp||Ralph/Bernadette Bassenger|
|Hugo Weaving||Anthony 'Tick' Belrose/Mitzi Del Bra|
|Guy Pearce||Adam Whitely/Felicia Jollygoodfellow|
|Alan Dargin||Aboriginal Man|
|June Marie Bennett||Shirley|
|Margaret Pomeranz||Adam's Mum|
When drag queen Anthony agrees to take his act on the road, he invites fellow cross-dresser Adam and transsexual Bernadette to come along. In their colorful bus, named Priscilla, the three performers travel across the Australian desert performing for enthusiastic crowds and homophobic locals. But when the other two performers learn the truth about why Anthony took the job, it threatens their act and their friendship.