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| Aaron Eckhart | Nick Naylor |
| Maria Bello | Polly Bailey |
| Cameron Bright | Joey Naylor |
| Adam Brody | Jack |
| Sam Elliott | Lorne Lutch |
| Katie Holmes | Heather Holloway |
| David Koechner | Bobby Jay Bliss |
| William H. Macy | Senator Finistirre |
| J.K. Simmons | BR |
| Robert Duvall | Captain |
| Kim Dickens | Jill Naylor |
| Rob Lowe | Jeff Megall |
| Todd Louiso | Ron Goode |
| Dennis Miller | TV Host |
Nick Naylor, a lobbyist for big tobacco, finds it difficult to balance his duties defending the dangerous substance with those of being a good role model for his young son. Nick's life gets even more complicated when a liberal senator mounts an anti-smoking campaign that he must counter. Based on the novel by Christopher Buckley.
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