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| Molly Shannon | Mary Katherine Gallagher |
| Will Ferrell | Sky Corrigan/Jesus |
| Elaine Hendrix | Evian Carrie Graham |
| Harland Williams | Eric Slater |
| Mark McKinney | Father Tylenol Ritley |
| Glynis Johns | Grandma Gallagher |
| Emmy Laybourne | Helen Lewengrub |
Orphaned after the death of her parents and raised by her strict grandmother, awkward Roman Catholic high-school student Mary Katherine Gallagher dreams about dating popular student Sky Corrigan and becoming a star. To achieve both goals, Mary enters a talent contest, where her competitor is Sky's girlfriend, Evian Graham . Despite her grandmother's opposition, Mary prepares to win both the contest and Sky's affection.
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