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| Christopher Reeve | Clark Kent/Kal-El/Superman |
| Gene Hackman | Lex Luthor |
| Marlon Brando | Jor-El |
| Margot Kidder | Lois Lane |
| Ned Beatty | Otis |
| Jackie Cooper | Perry White |
| Marc McClure | Jimmy Olsen |
| Glenn Ford | Jonathan Kent |
| Valerie Perrine | Eve Teschmacher |
| Phyllis Thaxter | Martha Kent |
| Jeff East | Young Clark Kent |
| Trevor Howard | First Elder |
| Susannah York | Lara |
| Maria Schell | Vond-Ah |
| Terence Stamp | General Zod |
| Sarah Douglas | Ursa |
| Harry Andrews | 2nd Elder |
| Lise Hilboldt | Secretary #1 |
| Larry Hagman | Major |
| John Ratzenberger | Controller #1 |
Jor-El of Krypton sends his baby to Earth, where he grows up as Clark Kent and works at the Daily Planet.
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