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| Ralph Bellamy | Franklin Delano Roosevelt |
| Greer Garson | Eleanor Roosevelt |
| Hume Cronyn | Louis Howe |
| Jean Hagen | Missy Le Hand |
| Ann Shoemaker | Sara Delano Roosevelt |
| Alan Bunce | Gov. Alfred E. Smith |
| Tim Considine | James Roosevelt |
| Zina Bethune | Anna Roosevelt |
| Pat Close | Elliott Roosevelt |
| Robin Warga | Franklin D. Roosevelt Jr. |
| Tom Carty | Johnny Roosevelt |
| Lyle Talbot | Mr. Brimmer |
| David White | Mr. Lassiter |
| Herbert Anderson | Daly |
In the summer of 1921, unsuccessful vice-presidential candidate Franklin Delano Roosevelt is vacationing with his family at their estate on Campobello Island on the Maine/New Brunswick border. During their stay, the 39-year-old Roosevelt comes down with a fever and sudden paralysis that is eventually diagnosed as polio. With the help of his wife, Eleanor, and his close friend and political consultant, Louis Howe, FDR battles his newfound disability.
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