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| John Leguizamo | Vinny |
| Adrien Brody | Richie |
| Mira Sorvino | Dionna |
| Jennifer Esposito | Ruby |
| Anthony LaPaglia | Detective Lou Petrocelli |
| Bebe Neuwirth | Gloria |
| Patti LuPone | Helen |
| Ben Gazzara | Luigi |
| Joe Lisi | Tony Olives |
| Michael Badalucco | Son of Sam |
| Michael Rispoli | Joe T |
| John Savage | Simon |
| Roger Guenveur Smith | Detective Curt Atwater |
| Saverio Guerra | Woodstock |
| Brian Tarantina | Bobby Del Fiore |
| Arthur Nascarella | Mario |
| Jimmy Breslin | Himself |
| Al Palagonia | Anthony |
| Ken Garito | Brian |
| Mike Starr | Eddie |
| Spike Lee | Reporter John Jeffries |
| James Reno | Crony |
| Lucia Grillo | Chiara |
| Nelson Vasquez | Officer Cruz |
| Darielle Gilad | Debbie Cadabra |
| Michael Harper | Raygun |
| Jessica Galbreath | Fire |
| Evan Cohen | Bite |
| George Tabb | Spider |
Working-class people live in terror as the Son of Sam killer, David Berkowitz, rampages in the Bronx.
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