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| Geraldine Page | Alma Winemiller |
| Laurence Harvey | John Buchanan, Jr. |
| Rita Moreno | Rosa Zacharias |
| Una Merkel | Mrs. Winemiller |
| John McIntire | Dr. Buchanan |
| Thomas Gomez | Papa Zacharias |
| Pamela Tiffin | Nellie Ewell |
| Malcolm Atterbury | Rev. Winemiller |
| Lee Patrick | Mrs. Ewell |
| Casey Adams | Roger Doremus |
| Earl Holliman | Archie Kramer |
| Harry Shannon | Dr. Burke (uncredited) |
| Pattee Chapman | Cynthia (uncredited) |
| Jester Hairston | Thomas (uncredited) |
| Pepe Hern | Nico (uncredited) |
| Dick Ryan | Dr. Hodges (uncredited) |
A preacher's daughter lusts for a doctor's son in circa-1916 Mississippi.
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