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| Elizabeth Taylor | Catherine Holly |
| Montgomery Clift | Dr. Cukrowicz |
| Katharine Hepburn | Mrs. Venable |
| Albert Dekker | Dr. Hockstader |
| Mercedes McCambridge | Mrs. Holly |
| Gene Raymond | George Holly |
| Mavis Villiers | Miss Foxhill |
| Patricia Marmont | Nurse Benson |
| Joan Young | Sister Felicity |
| Maria Britneva | Lucy |
| Sheila Robbins | Dr. Hockstader's Secretary |
| David Cameron | Young Blonde Intern |
| Roberta Woolley | A Patient (uncredited) |
In this adaptation of Tennessee Williams' play, young socialite Catherine Holly is traumatized and committed after witnessing her cousin's violent death on a trip to Europe. Her aunt, Violet Venable, wants to hide the events of her son's death and attempts to bribe young surgeon Dr. John Cukrowicz to perform a lobotomy on Catherine. But John vows to find out the truth about Catherine's state before taking any action.
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