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| Will Ferrell | Harold Crick |
| Maggie Gyllenhaal | Ana Pascal |
| Dustin Hoffman | Dr. Jules Hilbert |
| Queen Latifah | Penny Escher |
| Emma Thompson | Kay Eiffel |
| Tony Hale | Dave |
| Tom Hulce | Dr. Cayly |
| Linda Hunt | Dr. Mittag-Lefler |
| Eli Goodman | Augustus Chatman |
| Denise Hughes | Carla |
| Jason Burke | Commuter |
| Linara Washington | Bakery Assistant |
A mentally unstable IRS auditor hears an author's voice in his head and discovers that he is the ill-fated protagonist of her latest work. While a book-company employee tries to cure the author's case of writer's block, the auditor and a professor set out to find the woman and make her change her story.
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