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| Dolly Parton | Shirlee Kenyon |
| James Woods | Jack Russell |
| Griffin Dunne | Alan Riegert |
| Michael Madsen | Steve |
| Deirdre O'Connell | Lily |
| John Sayles | Guy Girardi |
| Teri Hatcher | Janice |
| Spalding Gray | Dr. Erdman |
| Jerry Orbach | Milo Jacoby |
| Philip Bosco | Gene Perlman |
| Charles Fleischer | Tony |
| Keith MacKechnie | Gordon |
| Jay Thomas | Zim Zimmerman |
| Amy Morton | Ann |
Leaving her rural life in Arkansas, Shirlee Kenyon moves to Chicago and seeks employment at a radio station. When a mix-up finds Shirlee sitting in as the host on a show for call-in advice, her common-sense wisdom wins over fans. Soon she's ''Doctor Shirlee,'' an in-demand on-air personality, but, of course, she's lacking in the proper credentials, a fact that journalist Jack Russell already suspects. Will Shirlee be able to keep her new gig if the truth gets out?
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