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| Patricia Arquette | Frankie Paige |
| Gabriel Byrne | Father Andrew Kiernan |
| Jonathan Pryce | Cardinal Daniel Houseman |
| Nia Long | Donna Chadway |
| Thomas Kopache | Father Durning |
| Rade Sherbedgia | Marion Petrocelli |
| Enrico Colantoni | Father Dario |
| Dick Latessa | Father Gianni Delmonico |
| Portia de Rossi | Jennifer Kelliho |
| Patrick Muldoon | Steven |
| Ann Cusack | Dr. Reston |
| Shaun Toub | Doctor |
| Tom Hodges | E.R. Nurse |
| Lydia Hazan | Attending Nurse |
| Duke Moosekian | Dr. Eckworth |
| Valarie Trapp | Woman with a Baby |
| Kessia Kordelle | Cheryl |
| Frankie Thorn | Donna's Customer |
| Mariah Nunn | Sister Angela |
| Tom Fahn | MTA Man |
| Marilyn Pitzer | Homeless Woman |
| Jack Donner | Father Alameida |
| Richard Conti | Valet Priest |
| Mary Linda Phillips | Sister Agnes |
| Liz Cruz | Waitress |
| Faith Christopher | Waitress |
| Joe Ruffo | Guard |
| Frederico Scutti | Guard |
| William Howell | Aerialist |
An atheist's visions and manifestations of wounds like those of the crucified Christ prompt the Vatican to send an investigator .
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