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| Patricia Arquette | Frankie Paige |
| Gabriel Byrne | Father Andrew Kiernan |
| Jonathan Pryce | Cardinal Daniel Houseman |
| Nia Long | Donna Chadway |
| Thomas Kopache | Father Durning |
| Rade Sherbedgia | Marion Petrocelli |
| Enrico Colantoni | Father Dario |
| Dick Latessa | Father Gianni Delmonico |
| Portia de Rossi | Jennifer Kelliho |
| Patrick Muldoon | Steven |
| Ann Cusack | Dr. Reston |
| Shaun Toub | Doctor |
| Tom Hodges | E.R. Nurse |
| Lydia Hazan | Attending Nurse |
| Duke Moosekian | Dr. Eckworth |
| Valarie Trapp | Woman with a Baby |
| Kessia Kordelle | Cheryl |
| Frankie Thorn | Donna's Customer |
| Mariah Nunn | Sister Angela |
| Tom Fahn | MTA Man |
| Marilyn Pitzer | Homeless Woman |
| Jack Donner | Father Alameida |
| Richard Conti | Valet Priest |
| Mary Linda Phillips | Sister Agnes |
| Liz Cruz | Waitress |
| Faith Christopher | Waitress |
| Joe Ruffo | Guard |
| Frederico Scutti | Guard |
| William Howell | Aerialist |
A young woman with no strong religious beliefs, Frankie Paige begins having strange and violent experiences, showing signs of the wounds that Jesus received when crucified. When the Vatican gets word of Frankie's situation, a high-ranking cardinal requests that the Rev. Andrew Kiernan investigate her case. Soon Kiernan realizes that very sinister forces are at work, and tries to rescue Frankie from the entity that is plaguing her.
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