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| Tilda Swinton | Lydie Crane |
| Amber Tamblyn | Stephanie Daley |
| Timothy Hutton | Paul |
| Denis O'Hare | Frank |
| Jim Gaffigan | Joe |
| Deirdre O'Connell | Jane |
| Halley Feiffer | Rhana |
| Neal Huff | Mr. Thomas |
| Kel O'Neill | Casey White |
| John Ellison Conlee | Jack Hutchinson |
| Vincent Piazza | Jeff |
| Caitlin Van Zandt | Satin |
| Marceline Hugot | Health Teacher |
| Kaiulani Lee | Reverend |
| Novella Nelson | Dr. Peterson |
| Melissa Leo | Miri |
Forensic psychologist Lydie Crane, who once had a stillbirth and is pregnant again, takes on a personally difficult case. She must examine Stephanie Daley, a teenager who is about to stand trial for the murder of her newborn. Flashbacks reveal Stephanie's past, as the teen recounts her version of events leading to her pregnancy, her labor and her infant's death.
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