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| William Shatner | Captain James T. Kirk |
| Leonard Nimoy | Captain Spock |
| DeForest Kelley | Commander Leonard H. McCoy, M.D. |
| James Doohan | Captain Montgomery Scott |
| Walter Koenig | Commander Pavel Andreievich Chekov |
| Nichelle Nichols | Commander Nyota Uhura |
| George Takei | Commander Hikaru Sulu |
| David Warner | St. John Talbot |
| Laurence Luckinbill | Sybok |
| Charles Cooper | General Korrd |
| Cynthia Gouw | Caithlin Dar |
| Todd Bryant | Captain Klaa |
| Spice Williams | Vixis |
| Rex Holman | J'Onn |
| George Murdock | God |
| Cynthia Blaise | Young Amanda Grayson |
| Bill Quinn | David McCoy |
A renegade Vulcan makes Kirk, Spock, McCoy and the Enterprise go to a planet at the center of the galaxy.
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