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| Patrick Stewart | Captain Jean-Luc Picard |
| Jonathan Frakes | Commander William T. Riker |
| Brent Spiner | Lieutenant Commander Data |
| LeVar Burton | Lieutenant Commander Geordi LaForge |
| Michael Dorn | Lieutenant Commander Worf |
| Marina Sirtis | Commander Deanna Troi |
| Gates McFadden | Dr. Beverly Crusher |
| Tom Hardy | Shinzon |
| Ron Perlman | Viceroy |
| Shannon Cochran | Senator Tal'aura |
| Dina Meyer | Commander Donatra |
| Jude Ciccolella | Commander Suran |
| Alan Dale | Praetor Hiren |
| John Berg | Senator |
| Michael Owen | Helm Officer Branson |
| Kate Mulgrew | Captain Kathryn Janeway |
| Robertson Dean | Reman Officer |
| David Ralphe | Commander |
| J. Patrick McCormack | Commander |
| Wil Wheaton | Wesley Crusher |
| Majel Barrett Roddenberry | Computer Voice |
The crew of the Enterprise must prevent a replica of Capt. Picard from overtaking Earth.
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