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| Antonio Banderas | Gregorio Cortez |
| Carla Gugino | Ingrid Cortez |
| Alexa Vega | Carmen Cortez |
| Daryl Sabara | Juni Cortez |
| Alan Cumming | Fegan Floop |
| Tony Shalhoub | Alexander Minion |
| Teri Hatcher | Mrs. Gradenko |
| Cheech Marin | Felix Gumm |
| Robert Patrick | Mr. Lisp |
| Danny Trejo | Isidor 'Machete' Cortez |
| Mike Judge | Donnagon/Donnamight |
| Richard Linklater | Cool Spy |
| Guillermo Navarro | Pastor |
| Johnny Reno | Agent Johnny |
| Shannon Shea | FoOglie No. 1/Flower |
| Norman Cabrera | FoOglie No. 2/Tall & Skinny |
| Trant Batey | FoOglie No. 3/Too Too |
| Andy W. Bossley | Brat |
| Jeff Dashnaw | Brat's Dad |
| Kara Slack | Carmen's Friend |
| Ehrmahn Ospina | Cab Driver |
| Emilio Navarro Mackissack | Excited Kid at Playground |
| Evan Sabara | Intruder Spy Kid |
| Rachel Duhame | President's Robot Daughter |
| Houston Hooker | Lisp's Robot Son |
| Louis Black | Financier |
| Charles Ramirez-Berg | Financier |
| Dick Clark | Financier |
| Steve Havens | Financier |
| Roberto Santibanez | Financier |
When a technical genius kidnaps retired spies, only their children can save them.
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