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| Antonio Banderas | Gregorio Cortez |
| Carla Gugino | Ingrid Cortez |
| Alexa Vega | Carmen Cortez |
| Daryl Sabara | Juni Cortez |
| Ricardo Montalban | Grandpa Cortez |
| Holland Taylor | Grandma Cortez |
| Sylvester Stallone | The Toymaker |
| Mike Judge | Donnagon Giggles |
| Emily Osment | Gertie Giggles |
| Cheech Marin | Uncle Felix |
| Bobby Edner | Francis |
| Courtney Jines | Demetra |
| Ryan James Pinkston | Arnold |
| Robert Vito | Rez |
| Danny Trejo | Machete |
| Alan Cumming | Floop |
| Tony Shalhoub | Alexander Minion |
| Salma Hayek | Francesca Giggles |
| Steve Buscemi | Romero |
| Bill Paxton | Dinky Winks |
| George Clooney | Devlin |
| Elijah Wood | The GUY |
A boy tries to rescue his sister inside a virtual-reality game created by a madman out to enslave children.
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