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| Tobey Maguire | Peter Parker/Spider-Man |
| Willem Dafoe | Norman Osborne/Green Goblin |
| Kirsten Dunst | Mary Jane Watson |
| James Franco | Harry Osborn |
| Cliff Robertson | Ben Parker |
| Rosemary Harris | May Parker |
| J.K. Simmons | J. Jonah Jameson |
| Joe Manganiello | Flash Thompson |
| Gerry Becker | Maximillian Fargas |
| Bill Nunn | Joseph "Robbie" Robertson |
| Jack Betts | Henry Balkan |
| Stanley Anderson | General Slocum |
| Ron Perkins | Dr. Mendel Stromm |
``Spider-Man'' centers on student Peter Parker who, after being bitten by a genetically-altered spider, gains superhuman strength and the spider-like ability to cling to any surface. He vows to use his abilities to fight crime, coming to understand the words of his beloved Uncle Ben: ``With great power comes great responsibility.''
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