| Anna Faris | Jane |
| Danny Masterson | Steve |
| Adam Brody | Dealer |
| Jane Lynch | Casting Director |
| John Krasinski | Brevin |
| Marion Ross | Shirley |
| Michael Hitchcock | Laundry Room Guy |
| John Cho | Mikey |
| Danny Trejo | Albert |
| Roscoe Lee Browne | Himself |
Jane, a struggling but perpetually stoned actress, has a busy day ahead. She has several important tasks on her list, including buying more marijuana. Even though she already has a good start on the day's planned drug use, she eats her roommate's pot-laced cupcakes and embarks on a series of misadventures all over Los Angeles.
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