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| Devon Sawa | Dave |
| Jason Schwartzman | Ethan |
| James King | Angela |
| Jason Segel | Sam |
| Joe Flaherty | Mr. Leonard |
| Michael Maronna | Jeff |
| Leigh Taylor-Young | Valerie Patton |
| Sam Anderson | Charles Patton |
| Laura Prepon | Reanna |
| Jim Rash | Head T.A. Philip |
| Cameron Diaz | Herself |
Dave, Sam and Jeff are about to graduate from Holden University with honors in lying, cheating and scheming. The three roommates have proudly scammed their way through the last four years of college and now, during final exams, these big-men-on-campus are about to be busted by the most unlikely dude in school. Self-dubbed Cool Ethan, an ambitious nerd with a bad crush, enters their lives one day and everything begins to unravel.
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