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| Rosalind Russell | Elizabeth Kenny |
| Alexander Knox | Dr. McDonnell |
| Dean Jagger | Kevin Connors |
| Philip Merivale | Dr. Brack |
| Beulah Bondi | Mary Kenny |
| Charles Dingle | Michael Kenny |
| John Litel | Medical Director |
| Doreen McCann | Dorrie |
| Fay Helm | Mrs. McIntyre |
| Charles Kemper | Mr. McIntyre |
| Dorothy Peterson | Agnes |
| Gloria Holden | Mrs. McDonnell |
| Virginia Brissac | Mrs. Johnson |
| Frank Reicher | Dr. Chuter |
| Paul Stanton | Dr. Gideon |
| Charles Halton | Mr. Smith |
| Alan Lee | Alan |
| Lloyd Ingraham | Farmer |
| Ellen Corby | Hospital Scrub Woman |
| Nan Leslie | Nurse |
| Egon Brecher | Frenchman |
| Lumsden Hare | Dr. Shadrack |
| Regis Toomey | New York Reporter |
| Lee Bonnell | San Francisco Reporter |
While working in the outback, Australian nurse Elizabeth Kenny encounters polio in some of her patients and witnesses its severe effects. As she treats many young children and babies, Kenny starts to develop theories about how to fight the disease, including hot presses on the afflicted limbs. When the medical community disputes her methods, Kenny sacrifices much of her personal life to convince doctors around the world that her practices are the best treatment.
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