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| Jessica Alba | Nancy Callahan |
| Devon Aoki | Miho |
| Alexis Bledel | Becky |
| Powers Boothe | Senator Rourk |
| Rosario Dawson | Gail |
| Benicio Del Toro | Jack Rafferty |
| Michael Clarke Duncan | Manute |
| Carla Gugino | Lucille |
| Josh Hartnett | The Salesman |
| Rutger Hauer | Cardinal Roark |
| Jaime King | Goldie/Wendy |
| Michael Madsen | Bob |
| Brittany Murphy | Shellie |
| Clive Owen | Dwight |
| Mickey Rourke | Marv |
| Nick Stahl | Junior/Yellow Bastard |
| Bruce Willis | John Hartigan |
| Elijah Wood | Kevin |
| Marley Shelton | The Customer |
| Maria Bello | Ava Lord |
| Arie Verveen | Murphy |
| Jason Douglas | Hitman |
Lawmen, prostitutes, a hulking thug and other sordid characters run amok in a crime-ridden metropolis.
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