| Mike Myers | Shrek |
| Eddie Murphy | Donkey |
| Cameron Diaz | Princess Fiona |
| Antonio Banderas | Puss in Boots |
| Rupert Everett | Prince Charming |
| Justin Timberlake | Prince Artie |
| Julie Andrews | Queen Lillian |
| John Cleese | King Harold |
| Eric Idle | Merlin |
| Cheri Oteri | Sleeping Beauty |
| Amy Poehler | Snow White |
| Maya Rudolph | Rapunzel |
| Amy Sedaris | Cinderella |
| John Krasinski | Sir Lancelot |
| Ian McShane | Captain Hook |
| Larry King | Doris |
| Regis Philbin | Mabel |
| Susan Blakeslee | Evil Queen |
| Cody Cameron | Pinocchio/Three Pigs |
| Seth Rogen | Ship Captain |
| Conrad Vernon | Gingerbread Man |
| Aron Warner | Wolf |
| Christopher Knights | Blind Mice |
When King Harold suddenly croaks, Shrek learns he will have to rule the land of Far, Far Away, unless he can find a suitable heir to the throne. The most-promising candidate is Princess Fiona's cousin Artie, a teenage slacker in a medieval high-school. Shrek and his trusted companions, Donkey and Puss in Boots, set out to bring Artie back but find their mission is a bigger challenge than they expected.
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