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| Andie MacDowell | Ann Finnigan |
| Bruce Davison | Howard Finnigan |
| Julianne Moore | Marian Wyman |
| Matthew Modine | Dr. Ralph Wyman |
| Lily Tomlin | Doreen Piggot |
| Tom Waits | Earl Piggot |
| Robert Downey Jr. | Bill Bush |
| Christopher Penn | Jerry Kaiser |
| Jennifer Jason Leigh | Lois Kaiser |
| Lyle Lovett | Andy Bitkower |
| Huey Lewis | Vern Miller |
| Buck Henry | Gordon Johnson |
| Fred Ward | Stuart Kane |
| Anne Archer | Claire Kane |
| Tim Robbins | Gene Shepard |
| Madeleine Stowe | Sherri Shepard |
| Peter Gallagher | Stormy Weathers |
| Lori Singer | Zoe Trainer / Cello (The Trout Quintet) |
| Frances McDormand | Betty Weathers |
| Annie Ross | Tess Trainer / Vocals |
| Robert DoQui | Knute Willis |
| Darnell Williams | Joe Robbins |
| Michael Beach | Jim Stone |
| Charles Rocket | Wally Littleton |
| Dirk Blocker | Diner Customer |
A study of the human condition examining the intertwined lives of 22 people. Based on Raymond Carver's stories.
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