| John Wayne | Captain Nathan Cutting Brittles |
| Joanne Dru | Olivia Dandridge |
| John Agar | Lt. Flint Cohill |
| Ben Johnson | Sgt. Tyree |
| Harry Carey Jr. | 2nd Lt. Ross Penell |
| Victor McLaglen | Top Sgt. Quincannon |
| Mildred Natwick | Abby Allshard aka Old Iron Pants |
| George O'Brien | Major Mac Allshard |
| Arthur Shields | Dr. O'Laughlin |
| Francis Ford | Connelly (uncredited) |
| Noble Johnson | Chief Red Shirt |
| Tom Tyler | Cpl. Mike Quayne |
| Frank McGrath | Bugler/Indian (uncredited) |
| Jack Pennick | Sergeant Major (uncredited) |
The last job of Calvary Captain Nathan Brittles before retirement is to soothe relations with the Cheyenne and Arapaho Indians after Custer's last stand. At the same time, he must transport the wife and niece of his commanding officer to a safe destination. After both his missions stall, Brittles attempts a face-to-face meeting with an important Native American chief in order to stave off an impending war.
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