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| Anthony Mackie | Jack |
| Kerry Washington | Fatima |
| Ellen Barkin | Margo |
| Monica Bellucci | Simona Bonasera |
| Jim Brown | Geronimo Armstrong |
| Ossie Davis | Qudge Buchanan |
| Jamel Debbouze | Doak |
| Brian Dennehy | Chairman Billy Church |
| Woody Harrelson | Powell |
| Bai Ling | Oni |
| Lonette McKee | Lottie |
| Paula Jai Parker | Evelyn |
| Q-Tip | Vada |
| Dania Ramirez | Alex |
| John Turturro | Don Angelo |
| Chiwetel Ejiofor | Frank Wills |
| Michole White | Nadiyah |
| Sarita Choudhury | Song |
Fired from his corporate job, a man agrees to impregnate his ex-fiancee and a slew of lesbians for money.
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