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| Samuel L. Jackson | John Shaft |
| Vanessa L. Williams | Carmen Vasquez |
| Jeffrey Wright | Peoples Hernandez |
| Christian Bale | Walter Wade, Jr. |
| Busta Rhymes | Rasaan |
| Dan Hedaya | Detective Jack Roselli |
| Toni Collette | Diane Palmieri |
| Richard Roundtree | Uncle John Shaft |
| Ruben Santiago-Hudson | Jimmy Groves |
| Josef Sommer | Curt Fleming |
| Lynne Thigpen | Carla Howard |
| Philip Bosco | Walter Wade, Sr. |
| Pat Hingle | Hon. Dennis Bradford |
| Lee Tergesen | Luger |
| Mekhi Phifer | Trey Howard |
A detective and a narcotics cop track a sociopath out to kill a woman who can testify that he committed murder.
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