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| Helen Mirren | Rose |
| Cuba Gooding Jr. | Mikey |
| Stephen Dorff | Clayton |
| Vanessa Ferlito | Vickie |
| Mo'Nique | Precious |
| Macy Gray | Neisha |
| Joseph Gordon-Levitt | Dr. Don |
| Matt Higgins | Eddie |
| Terria Joseph | Gloria |
| Ryan Sands | Ramone |
| Angel Oquendo | Lamar |
| Marilyn Yoblick | Mehta |
Rose is a highly efficient contract killer, and her stepson, Mikey, shares her profession and her bed. Learning she has terminal cancer, she determines to carry out one last hit, but her plans go awry when she discovers her next target is her latest employer's pregnant wife .
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