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| Brad Pitt | Detective David Mills |
| Morgan Freeman | Detective Lt. William Somerset |
| Gwyneth Paltrow | Tracy Mills |
| R. Lee Ermey | Police Captain |
| Richard Roundtree | Dist. Atty. Martin Talbot |
| John C. McGinley | California |
| Julie Araskog | Mrs. Gould |
| Mark Boone Junior | Greasy FBI Man |
| John Cassini | Officer Davis |
| Reginald E. Cathey | Coroner |
| Peter Crombie | Dr. O'Neill |
| Kevin Spacey | John Doe |
| Hawthorne James | George, Library Night Guard |
| Michael Massee | Man in Massage Parlour Booth |
| Leland Orser | Crazed Man in Massage Parlour |
| Richard Portnow | Dr. Beardsley |
| Richard Schiff | Mark Swarr (John Doe's Lawyer) |
| Pamela Tyson | Homeless Woman |
A meticulous detective and the young officer about to replace the veteran probe serial murders based on the seven deadly sins.
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