| David Arquette | Dwight "Dewey" Riley |
| Neve Campbell | Sidney Prescott |
| Courteney Cox Arquette | Gale Weathers |
| Patrick Dempsey | Detective Mark Kincaid |
| Scott Foley | Roman Bridger/Director |
| Lance Henriksen | John Milton/Director |
| Matt Keeslar | Tom Prinze/Dewey in Stab 3 |
| Jenny McCarthy | Sarah Darling/Candy in Stab 3 |
| Emily Mortimer | Angelina Tyler/Sidney in Stab 3 |
| Parker Posey | Jennifer Jolie/Gale in Stab 3 |
| Deon Richmond | Tyson Fox/Ricky in Stab 3 |
| Patrick Warburton | Steven Stone |
| Liev Schreiber | Cotton Weary |
| Heather Matarazzo | Martha Meeks |
| Jamie Kennedy | Randy Meeks |
| Carrie Fisher | Bianca Burnette |
| Kevin Smith | Silent Bob |
| Jason Mewes | Jay Phat Buds |
| Roger Corman | Sunrise Studios Executive |
In the final installment to this trilogy, a murdering spree begins to happen again; this time targeted toward the original Woodsboro survivors and those associated with the movie-inside a-movie, Stab 3. Sydney must face the demons of her past to stop the killer(s).
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