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| Freddie Prinze Jr. | Fred Jones |
| Sarah Michelle Gellar | Daphne Blake |
| Matthew Lillard | Norville 'Shaggy' Rogers |
| Linda Cardellini | Velma Dinkley |
| Rowan Atkinson | Mondavarious |
| Isla Fisher | Mary Jane |
| Miguel A. Núñez Jr. | Voodoo Maestro |
| Steven Grives | N' Goo Tuana |
| Sam Greco | Zarkos |
| Charles Cousins | Velma's Friend |
| Kristian Schmid | Brad |
| Nicholas Hope | Old Man Smithers |
Zoinks! Two years after a clash of egos forced Mystery Inc. to close its doors, Scooby-Doo and his clever crime-solving cohorts Fred, Daphne, Shaggy and Velma are individually summoned to Spooky Island to investigate a series of paranormal incidents at the ultra-hip Spring Break hot spot.
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