|Cary Elwes||Dr. Lawrence Gordon|
|Danny Glover||Detective David Tapp|
|Monica Potter||Alison Gordon|
|Michael Emerson||Zep Hindle|
|Ken Leung||Detective Steven Sing|
|Makenzie Vega||Diana Gordon|
Photographer Adam Stanheight and oncologist Lawrence Gordon regain consciousness while chained to pipes at either end of a filthy bathroom. As the two men realize they've been trapped by a sadistic serial killer nicknamed ''Jigsaw'' and must complete his perverse puzzle to live, flashbacks relate the fates of his previous victims. Meanwhile, Dr. Gordon's wife and young daughter are forced to watch his torture via closed-circuit video.