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| James Gandolfini | Nick Murder |
| Susan Sarandon | Kitty Kane |
| Kate Winslet | Tula |
| Steve Buscemi | Angelo |
| Christopher Walken | Cousin Bo |
| Bobby Cannavale | Fryburg |
| Mandy Moore | Baby |
| Mary-Louise Parker | Constance |
| Aida Turturro | Rosebud |
| Barbara Sukowa | Gracie |
| Elaine Stritch | Grace Murder |
| Eddie Izzard | Gene Vincent |
| Amy Sedaris | Frances |
| P.J. Brown | Police Officer |
| Cady Huffman | Female Dancer & Singer |
| Tonya Pinkins | Female Medic |
| David Thornton | Urologist |
| Kumar Pullana | Kumar |
| June Stein | Frances' Mother |
| Michael McElroy | Ten Commandments Priest |
| Joseph Longo | Altar Boy |
| Devon McRimmon | Altar Boy |
| Amedeo Turturro | Fryburg Friend |
| Ryan Webb | Fryburg Friend |
| Jacob Lumet-Cannavale | Fryburg Friend |
| Diego Turturro | Boy on Tricycle |
| Yianni Digaletos | The Greek |
| Katherine Borowitz | Female Dancer & Singer |
A blue-collar worker alienates his wife and three daughters when they learn he has a mistress .
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