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| Lucy Liu | Sadie |
| Michael Chiklis | Detective Rawlins |
| Carla Gugino | Eve |
| James D'Arcy | Bishop |
| Robert Forster | Lloyd |
| Cameron Goodman | Kaitlin |
| Margo Harshman | Trisha |
| Nick Lachey | Dwayne |
| Marilyn Manson | Bartender |
| Julio Oscar Mechoso | Arturo |
| Samaire Armstrong | Jenny |
| Allan Rich | Mr. Harrison |
| Cameron Richardson | Collette |
Sadie, a reporter, investigates an underground cult in Los Angeles which seems to be responsible for a series of grisly murders. While trying to discover the cult's secrets, she becomes a victim herself. Sadie awakes in the morgue with an insatiable craving for blood and revenge, so she joins forces with a grieving detective to destroy the undead creatures once and for all.
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