| Robert Alda | George Gershwin |
| Joan Leslie | Julie Adams |
| Alexis Smith | Christine Gilbert |
| Oscar Levant | Himself |
| Charles Coburn | Max Dreyfus |
| Julie Bishop | Lee Gershwin |
| Albert Basserman | Professor Franck |
| Morris Carnovsky | Morris Gershwin |
| Herbert Rudley | Ira Gershwin |
| Rosemary DeCamp | Rose Gershwin |
| Paul Whiteman | Himself |
| Hazel Scott | Herself |
From childhood, George Gershwin shows remarkable musical ability, and his parents place him in training with Professor Frank . Despite Frank's warning not to succumb to popular music, George focuses on show tunes and jazz. While he's studying, he performs at vaudeville theaters and tries to sell his songs in music stores. After Al Jolson sees success with his music, George's career takes off on Broadway and in Hollywood, before tragedy strikes.
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