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| Milla Jovovich | Alice |
| Oded Fehr | Carlos Olivera |
| Ali Larter | Claire |
| Iain Glen | Dr. Isaacs |
| Ashanti | Nurse Betty |
| Christopher Egan | Mikey |
| Spencer Locke | K-Mart |
| Matthew Marsden | Slater |
| Mike Epps | L.J. |
| Linden Ashby | Chase |
| Jason O'Mara | Albert Wesker |
| Joe Hursley | Otto |
More Resident Evil: Extinction Pictures
Captured by the Umbrella Corp., Alice receives genetic alterations that leave her with superhuman abilities. Hiding out in the Nevada desert, she joins forces with former cohorts Carlos and L.J. as well as new survivors Claire, K-Mart and Nurse Betty to eradicate the virus that threatens to turn every human on Earth into a zombie.
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