| Rosario Dawson | Mimi Marquez |
| Taye Diggs | Benjamin "Benny" Coffin III |
| Jesse L. Martin | Thomas B. "Tom" Collins |
| Idina Menzel | Maureen Johnson |
| Adam Pascal | Roger Davis |
| Anthony Rapp | Mark Cohen |
| Wilson Jermaine Heredia | Angel Schunard |
| Tracie Thomas | Joanne Jefferson |
| Aaron Lohr | Steve |
| Sarah Silverman | Alexi Darling |
| Wayne Wilcox | Gordon |
| Daryl Edwards | Mr. Jefferson |
| Daniel London | Paul |
Artists, junkies and misfits in New York's East Village struggle with poverty, illness and the AIDS epidemic.
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