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| Thomas Lennon | Lt. Jim Dangle |
| Ben Garant | Deputy Travis Junior |
| Kerri Kenney | Deputy Trudy Wiegel |
| Cedric Yarbrough | Deputy S. Jones |
| Carlos Alazraqui | Deputy James Garcia |
| Wendi McLendon-Covey | Deputy Clementine Johnson |
| Niecy Nash | Deputy Raineesha Williams |
| Mary Birdsong | Deputy Cheresa Kimball |
| Paul Rudd | The Druglord |
| Nick Swardson | Terry |
| Michael Ian Black | Ron of Ron's Tattoo |
| Danny DeVito | District Attorney |
| Patton Oswalt | Deputy Assistant Mayor, Jeff Spoder |
Bumbling officers of the Reno (Nevada) Police Department finally get an opportunity to attend a law-enforcement convention in Florida. Fun in the sun turns to serious business when terrorists launch a bioattack in the area. With every cop in Miami out sick, it is up to the intrepid Nevada cops to serve and protect the unfortunate populace.
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