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| Warren Beatty | John Reed |
| Diane Keaton | Louise Bryant |
| Jack Nicholson | Eugene O'Neill |
| Maureen Stapleton | Emma Goldman |
| Edward Herrmann | Max Eastman |
| Jerzy Kosinski | Grigory Zinoviev |
| Paul Sorvino | Louis Fraina |
| Nicolas Coster | Paul Trullinger |
| Ian Wolfe | Mr. Partlow |
| Bessie Love | Mrs. Partlow |
| MacIntyre Dixon | Carl Walters |
| Pat Starr | Helen Walters |
| Max Wright | Floyd Dell |
| Eleanor D. Wilson | Mrs. Reed |
American journalist John Reed journeys to Russia to document the Boleshevik Revolution and returns a revolutionary. His fervor for left-wing politics leads him to Louise Bryant, then married, who will become a feminist icon and activist. Politics at home become more complicated as the rift grows between reality and Reed's ideals. Bryant takes up with a cynical playwright, and Reed returns to Russia, where his health declines.
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