| Rachel McAdams | Lisa Reisert |
| Cillian Murphy | Jackson Rippner |
| Brian Cox | Joe Reisert |
| Jayma Mays | Cynthia |
| Jack Scalia | William Keefe |
| Kyle Gallner | Kevin |
| Carl Gilliard | Taxi Driver |
| Laura Johnson | Fortyish Woman |
| Max Kasch | Headphone Kid |
| Loren Lester | Irate Passenger |
| Monica McSwain | Young Flight Attendant |
| Brittany Oaks | Rebecca |
| Angela Paton | Nice Lady |
A plane passenger forcibly involves his seatmate in a plot to assassinate a government official.
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