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| Jamie Foxx | Ray Charles |
| Kerry Washington | Della Bea Robinson |
| Regina King | Margie Hendricks |
| Clifton Powell | Jeff Brown |
| Aunjanue Ellis | Mary Ann Fisher |
| Harry J. Lennix | Joe Adams |
| Terrence Dashon Howard | Gossie McKee |
| Larenz Tate | Quincy Jones |
| Bokeem Woodbine | Fathead Newman |
| Sharon Warren | Aretha Robinson |
| Curtis Armstrong | Ahmet Ertegun |
| Richard Schiff | Jerry Wexler |
| C.J. Sanders | Young Ray Robinson |
| Wendell Pierce | Wilbur Brassfield |
| Chris Thomas King | Lowell Fulson |
| David Krumholtz | Milt Shaw |
| Warwick Davis | Oberon |
| Patrick Bauchau | Dr. Hacker |
| Robert Wisdom | Jack Lauderdale |
| Denise Dowse | Marlene |
| Thomas Jefferson Byrd | Jimmy |
| Rick Gomez | Tom Dowd |
| Kurt Fuller | Sam Clark |
Blind since childhood, Ray Charles overcomes poverty, hardship and addiction and becomes an American music legend.
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