|Daniel Auteuil||Henri de Navarre|
|Jean-Hugues Anglade||Charles IX|
|Vincent Perez||La Môle|
|Virna Lisi||Catherine de Médicis|
|Dominique Blanc||Henriette de Nevers|
|Asia Argento||Charlotte of Sauve|
Margot is one of several in line to inherit the crown in France, where Roman Catholics and Protestants are jockeying for power. Margot's mother, Catherine de Medici, is intent on seeing her son take the throne once the reign of King Charles IX ends. After being married to a man she doesn't love and starting a tryst with one she does, Margot contends with her mother's at-all-costs plan to control the political fate of the volatile country.