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| Christina Ricci | Lizzie |
| Jason Biggs | Rafe |
| Anne Heche | Dr. Sterling |
| Michelle Williams | Ruby |
| Jonathan Rhys-Myers | Noah |
| Jessica Lange | Mrs. Wurtzel |
| Nicholas Campbell | Donald |
| Lou Reed | Himself |
| Sheila Paterson | Grandmother |
| Zoe Miller | Elizabeth at age 12 |
Based on the best selling novel, set in the mid 1980's before the prevalence of anti-depressants, it follows a young working class woman's bout with depression during her first year at Harvard. The film explores this generation's struggle to navigate the effects of divorce, drugs, sex, and an overbearing mother .
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