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| Gwyneth Paltrow | Catherine |
| Anthony Hopkins | Robert |
| Jake Gyllenhaal | Hal |
| Hope Davis | Claire |
| Gary Houston | Professor Jay Barrow |
| Roshan Seth | Professor Bhandari |
| Anne Wittman | Joanne |
| Leland Burnett | Eddy |
| Daniel Hatkoff | Student |
| John Keefe | Admirer |
| Haroula Spyropoulos | Student |
| Colin Stinton | Physicist at party |
Catherine is a 27-year-old grieving after the loss of her father, a genius mathematician whose mind gradually deteriorated from mental illness. With her sister, Claire, urging Catherine to leave their family home, and an ambitious student searching through her father's notes, Catherine struggles to keep her composure and her sanity in this drama adapted from the stage play by David Auburn.
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