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| Alec Baldwin | Peter Hoskins |
| Meg Ryan | Rita Boyle |
| Kathy Bates | Leah Blier |
| Ned Beatty | Doctor Boyle |
| Patty Duke | Mrs. Boyle |
| Sydney Walker | Old Man |
| Richard Riehle | Jerry Blier |
| Stanley Tucci | Taylor |
| Rocky Carroll | Tom |
Peter and Rita immediately fall for each other and decide to get married. But during their wedding reception, a feeble old man asks Rita for a kiss. While nothing seems wrong at first, Peter soon realizes that the kiss caused Rita and the man to switch bodies. As he searches for a way to switch them back, Peter must face the dilemma of loving Rita in the body of a terminally ill man or staying married to a stranger posing as his wife.
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